Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model

BACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson’s disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Inflamm Res
Main Authors: Jing, Lu, Hou, Liyan, Zhang, Dongdong, Li, Sheng, Ruan, Zhengzheng, Zhang, Xiaomeng, Hong, Jau-Shyong, Wang, Qingshan
Format: Artigo
Jezik:Inglês
Izdano: Dove 2021
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044341/
https://ncbi.nlm.nih.gov/pubmed/33859489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S299927
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki