Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model

BACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson’s disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated...

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Detalhes bibliográficos
Publicado no:J Inflamm Res
Main Authors: Jing, Lu, Hou, Liyan, Zhang, Dongdong, Li, Sheng, Ruan, Zhengzheng, Zhang, Xiaomeng, Hong, Jau-Shyong, Wang, Qingshan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044341/
https://ncbi.nlm.nih.gov/pubmed/33859489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S299927
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