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Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
Intra-tumor heterogeneity renders the identification of somatic single-nucleotide variants (SNVs) a challenging problem. In particular, low-frequency SNVs are hard to distinguish from sequencing artifacts. While the increasing availability of multi-sample tumor DNA sequencing data holds the potentia...
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| I publikationen: | Nat Commun |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2021
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8044184/ https://ncbi.nlm.nih.gov/pubmed/33850139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22466-9 |
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