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Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters

Norepinephrine is a biogenic amine neurotransmitter that has widespread effects on alertness, arousal and pain sensation. Consequently, blockers of norepinephrine uptake have served as vital tools to treat depression and chronic pain. Here, we employ the Drosophila melanogaster dopamine transporter...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pidathala, Shabareesh, Mallela, Aditya Kumar, Joseph, Deepthi, Penmatsa, Aravind
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044178/
https://ncbi.nlm.nih.gov/pubmed/33850134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22385-9
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