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Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters

Norepinephrine is a biogenic amine neurotransmitter that has widespread effects on alertness, arousal and pain sensation. Consequently, blockers of norepinephrine uptake have served as vital tools to treat depression and chronic pain. Here, we employ the Drosophila melanogaster dopamine transporter...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Pidathala, Shabareesh, Mallela, Aditya Kumar, Joseph, Deepthi, Penmatsa, Aravind
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044178/
https://ncbi.nlm.nih.gov/pubmed/33850134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22385-9
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