Identifying therapeutic drug targets using bidirectional effect genes

Prioritizing genes for translation to therapeutics for common diseases has been challenging. Here, we propose an approach to identify drug targets with high probability of success by focusing on genes with both gain of function (GoF) and loss of function (LoF) mutations associated with opposing effe...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Estrada, Karol, Froelich, Steven, Wuster, Arthur, Bauer, Christopher R., Sterling, Teague, Clark, Wyatt T., Ru, Yuanbin, Trinidad, Marena, Nguyen, Hong Phuc, Luu, Amanda R., Wendt, Daniel J., Yogalingam, Gouri, Yu, Guoying Karen, LeBowitz, Jonathan H., Cardon, Lon R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044152/
https://ncbi.nlm.nih.gov/pubmed/33850126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21843-8
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