In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer

Poly ADP-ribose polymerase (PARP) inhibitors are promising targeted therapy for epithelial ovarian cancer (EOC) with BRCA mutations or defective homologous recombination (HR) repair. However, reversion of BRCA mutation and restoration of HR repair in EOC lead to PARP inhibitor resistance and reduced...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Lin, Z. Ping, Al Zouabi, Nour N., Xu, Mark L., Bowen, Nicole E., Wu, Terence L., Lavi, Ethan S., Huang, Pamela H., Zhu, Yong-Lian, Kim, Baek, Ratner, Elena S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044145/
https://ncbi.nlm.nih.gov/pubmed/33850183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87325-5
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