Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer

PARP inhibitors target BRCA mutations and defective homologous recombination repair (HRR) for the treatment of epithelial ovarian cancer (EOC). However, the treatment of HRR-proficient EOC with PARP inhibitors remains challenging. The objective of this study was to determine whether the combination...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lin, Z. Ping, Zhu, Yong-Lian, Lo, Ying-Chun, Moscarelli, Jake, Xiong, Amy, Korayem, Yasmin, Huang, Pamela H., Giri, Smith, LoRusso, Patricia, Ratner, Elena S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239325/
https://ncbi.nlm.nih.gov/pubmed/30444904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207399
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