In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer

Poly ADP-ribose polymerase (PARP) inhibitors are promising targeted therapy for epithelial ovarian cancer (EOC) with BRCA mutations or defective homologous recombination (HR) repair. However, reversion of BRCA mutation and restoration of HR repair in EOC lead to PARP inhibitor resistance and reduced...

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Publicado no:Sci Rep
Main Authors: Lin, Z. Ping, Al Zouabi, Nour N., Xu, Mark L., Bowen, Nicole E., Wu, Terence L., Lavi, Ethan S., Huang, Pamela H., Zhu, Yong-Lian, Kim, Baek, Ratner, Elena S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044145/
https://ncbi.nlm.nih.gov/pubmed/33850183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87325-5
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