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Drosophila female germline stem cells undergo mitosis without nuclear breakdown
Stem cell homeostasis requires nuclear lamina (NL) integrity. In Drosophila germ cells, compromised NL integrity activates the ATR and Chk2 checkpoint kinases, blocking germ cell differentiation and causing germline stem cell (GSC) loss. Checkpoint activation occurs upon loss of either the NL protei...
Shranjeno v:
| izdano v: | Curr Biol |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8044017/ https://ncbi.nlm.nih.gov/pubmed/33548191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2021.01.033 |
| Oznake: |
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