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Identification of highly selective covalent inhibitors by phage display
Molecules that covalently bind macromolecular targets have found widespread applications as activity-based probes and as irreversibly binding drugs. However, the general reactivity of the electrophiles needed for covalent bond formation makes control of selectivity difficult. There is currently no r...
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| Publicado no: | Nat Biotechnol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8043995/ https://ncbi.nlm.nih.gov/pubmed/33199876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0733-7 |
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