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SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation
We have previously shown that overexpression of SKI, an endogenous TGF-β(1) repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hippo tumor-suppressor pathway and inhibiting the Tra...
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| Yayımlandı: | Basic Res Cardiol |
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| Asıl Yazarlar: | , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Springer Berlin Heidelberg
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8043893/ https://ncbi.nlm.nih.gov/pubmed/33847835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-021-00865-9 |
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