SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

We have previously shown that overexpression of SKI, an endogenous TGF-β(1) repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hippo tumor-suppressor pathway and inhibiting the Tra...

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Bibliografske podrobnosti
izdano v:Basic Res Cardiol
Main Authors: Landry, Natalie M., Rattan, Sunil G., Filomeno, Krista L., Meier, Thomas W., Meier, Simon C., Foran, Sarah J., Meier, Claire F., Koleini, Navid, Fandrich, Robert R., Kardami, Elissavet, Duhamel, Todd A., Dixon, Ian M. C.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2021
Teme:
Original Contribution
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043893/
https://ncbi.nlm.nih.gov/pubmed/33847835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-021-00865-9
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