SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation

We have previously shown that overexpression of SKI, an endogenous TGF-β(1) repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hippo tumor-suppressor pathway and inhibiting the Tra...

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Detaylı Bibliyografya
Yayımlandı:Basic Res Cardiol
Asıl Yazarlar: Landry, Natalie M., Rattan, Sunil G., Filomeno, Krista L., Meier, Thomas W., Meier, Simon C., Foran, Sarah J., Meier, Claire F., Koleini, Navid, Fandrich, Robert R., Kardami, Elissavet, Duhamel, Todd A., Dixon, Ian M. C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2021
Konular:
Original Contribution
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043893/
https://ncbi.nlm.nih.gov/pubmed/33847835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-021-00865-9
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