Gut microbiota-specific IgA(+) B cells traffic to the CNS in active multiple sclerosis

Changes in gut microbiota composition and a diverse role of B cells have recently been implicated in multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease. Immunoglobulin A (IgA) is a key regulator at the mucosal interface. However, whether gut microbiota shape IgA responses and...

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Publicado en:Sci Immunol
Autores principales: Pröbstel, Anne-Katrin, Zhou, Xiaoyuan, Baumann, Ryan, Wischnewski, Sven, Kutza, Michael, Rojas, Olga L., Sellrie, Katrin, Bischof, Antje, Kim, Kicheol, Ramesh, Akshaya, Dandekar, Ravi, Greenfield, Ariele L., Schubert, Ryan D., Bisanz, Jordan E., Vistnes, Stephanie, Khaleghi, Khashayar, Landefeld, James, Kirkish, Gina, Liesche-Starnecker, Friederike, Ramaglia, Valeria, Singh, Sneha, Tran, Edwina B., Barba, Patrick, Zorn, Kelsey, Oechtering, Johanna, Forsberg, Karin, Shiow, Lawrence R., Henry, Roland G., Graves, Jennifer, Cree, Bruce A. C., Hauser, Stephen L., Kuhle, Jens, Gelfand, Jeffrey M., Andersen, Peter M., Schlegel, Jürgen, Turnbaugh, Peter J., Seeberger, Peter H., Gommerman, Jennifer L., Wilson, Michael R., Schirmer, Lucas, Baranzini, Sergio E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043673/
https://ncbi.nlm.nih.gov/pubmed/33219152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abc7191
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