Gut microbiota-specific IgA(+) B cells traffic to the CNS in active multiple sclerosis

Changes in gut microbiota composition and a diverse role of B cells have recently been implicated in multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease. Immunoglobulin A (IgA) is a key regulator at the mucosal interface. However, whether gut microbiota shape IgA responses and...

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Опубликовано в: :Sci Immunol
Главные авторы: Pröbstel, Anne-Katrin, Zhou, Xiaoyuan, Baumann, Ryan, Wischnewski, Sven, Kutza, Michael, Rojas, Olga L., Sellrie, Katrin, Bischof, Antje, Kim, Kicheol, Ramesh, Akshaya, Dandekar, Ravi, Greenfield, Ariele L., Schubert, Ryan D., Bisanz, Jordan E., Vistnes, Stephanie, Khaleghi, Khashayar, Landefeld, James, Kirkish, Gina, Liesche-Starnecker, Friederike, Ramaglia, Valeria, Singh, Sneha, Tran, Edwina B., Barba, Patrick, Zorn, Kelsey, Oechtering, Johanna, Forsberg, Karin, Shiow, Lawrence R., Henry, Roland G., Graves, Jennifer, Cree, Bruce A. C., Hauser, Stephen L., Kuhle, Jens, Gelfand, Jeffrey M., Andersen, Peter M., Schlegel, Jürgen, Turnbaugh, Peter J., Seeberger, Peter H., Gommerman, Jennifer L., Wilson, Michael R., Schirmer, Lucas, Baranzini, Sergio E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043673/
https://ncbi.nlm.nih.gov/pubmed/33219152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abc7191
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