Single-Cell Circulating Tumor Cell Analysis Reveals Genomic Instability as a Distinctive Feature of Aggressive Prostate Cancer

PURPOSE: Aggressive variant prostate cancer (AVPC) represents a clinical subset distinguished by therapy resistance and poor prognosis, linked to combined losses of the tumor suppressor genes (TSG) PTEN, RB1, and TP53. Circulating tumor cells (CTC) provide a minimally invasive opportunity for identi...

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Pubblicato in:Clin Cancer Res
Autori principali: Malihi, Paymaneh D., Graf, Ryon P., Rodriguez, Angel, Ramesh, Naveen, Lee, Jerry, Sutton, Ramsay, Jiles, Rhett, Velasco, Carmen Ruiz, Sei, Emi, Kolatkar, Anand, Logothetis, Christopher, Navin, Nicholas E., Corn, Paul, Aparicio, Ana M., Dittamore, Ryan, Hicks, James, Kuhn, Peter, Zurita, Amado J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043601/
https://ncbi.nlm.nih.gov/pubmed/32341031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-4100
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