FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

Repetitive elements (REs) compose ~50% of the human genome and are normally transcriptionally silenced, although the mechanism has remained elusive. Through an RNAi screen, we identified FBXO44 as an essential repressor of REs in cancer cells. FBXO44 bound H3K9me3-modified nucleosomes at the replica...

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Pubblicato in:Cell
Autori principali: Shen, Jia Z., Qiu, Zhixin, Wu, Qiulian, Finlay, Darren, Garcia, Guillermina, Sun, Dahui, Rantala, Juha, Barshop, William, Hope, Jennifer L., Gimple, Ryan C., Sangfelt, Olle, Bradley, Linda M., Wohlschlegel, James, Rich, Jeremy N., Spruck, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043252/
https://ncbi.nlm.nih.gov/pubmed/33357448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.042
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