FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

Repetitive elements (REs) compose ~50% of the human genome and are normally transcriptionally silenced, although the mechanism has remained elusive. Through an RNAi screen, we identified FBXO44 as an essential repressor of REs in cancer cells. FBXO44 bound H3K9me3-modified nucleosomes at the replica...

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Publicado en:Cell
Autores principales: Shen, Jia Z., Qiu, Zhixin, Wu, Qiulian, Finlay, Darren, Garcia, Guillermina, Sun, Dahui, Rantala, Juha, Barshop, William, Hope, Jennifer L., Gimple, Ryan C., Sangfelt, Olle, Bradley, Linda M., Wohlschlegel, James, Rich, Jeremy N., Spruck, Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043252/
https://ncbi.nlm.nih.gov/pubmed/33357448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.11.042
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