Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6–HMGB1 deacetylation

BACKGROUND: Vascular calcification associated with chronic kidney disease (CKD) can increase the risk of mortality. Elevated serum levels of high mobility group box 1 (HMGB1) promotes vascular calcification in CKD via the Wnt/β-catenin pathway. Sirtuin 6 (SIRT6) prevents fibrosis in CKD by blocking...

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Udgivet i:Stem Cell Res Ther
Main Authors: Wei, Wenqian, Guo, Xiaodong, Gu, Lijie, Jia, Jieshuang, Yang, Man, Yuan, Weijie, Rong, Shu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042866/
https://ncbi.nlm.nih.gov/pubmed/33849640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02307-8
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