Antihypertensive Effect of a Novel Angiotensin II Receptor Blocker Fluorophenyl Benzimidazole: Contribution of cGMP, Voltage-dependent Calcium Channels, and BK(Ca) Channels to Vasorelaxant Mechanisms

Background: The current study presents the novel angiotensin II receptor blocker fluorophenyl benzimidazole (FPD) as an antihypertensive agent in the SHR model of hypertension. We investigated the role of cGMP, voltage-dependent L-type calcium channels, and BK(Ca) channels in the vasorelaxant mechan...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Iqbal, Hina, Verma, Amit Kumar, Yadav, Pankaj, Alam, Sarfaraz, Shafiq, Mohammad, Mishra, Divya, Khan, Feroz, Hanif, Kashif, Negi, Arvind Singh, Chanda, Debabrata
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042648/
https://ncbi.nlm.nih.gov/pubmed/33859561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.611109
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