Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BK(Ca) channels and reducing intracellular Ca(2+) levels

AIM: Sustained pulmonary vasoconstriction as experienced at high altitude can lead to pulmonary hypertension (PH). The main purpose of this study is to investigate the vasorelaxant effect of echinacoside (ECH), a phenylethanoid glycoside from the Tibetan herb Lagotis brevituba Maxim and Cistanche tu...

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Bibliographische Detailangaben
Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: Gai, Xiang-yun, Wei, Yu-hai, Zhang, Wei, Wuren, Ta-na, Wang, Ya-ping, Li, Zhan-qiang, Liu, Shou, Ma, Lan, Lu, Dian-xiang, Zhou, Yi, Ge, Ri-li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422939/
https://ncbi.nlm.nih.gov/pubmed/25864652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.126
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