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SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function
SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein degradation and decreased transporter activity. Next-generation...
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| 發表在: | Drug Metab Dispos |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Pharmacology and Experimental Therapeutics
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8042483/ https://ncbi.nlm.nih.gov/pubmed/33658230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000264 |
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