CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants

Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge for pharmacogenomics. Deep mutational scanning...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Clin Transl Sci
Autores principales: Zhang, Lingxin, Sarangi, Vivekananda, Moon, Irene, Yu, Jia, Liu, Duan, Devarajan, Sandhya, Reid, Joel M., Kalari, Krishna R., Wang, Liewei, Weinshilboum, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359949/
https://ncbi.nlm.nih.gov/pubmed/32004414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12758
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares