Gut Microbiota-Mediated Transformation of Coptisine Into a Novel Metabolite 8-Oxocoptisine: Insight Into Its Superior Anti-Colitis Effect

Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Coptis Chinemsis Franch, which is traditionally applied for the management of colitis. However, the blood concentration of COP was extremely low, and its gut microbiota-mediated metabolites were thought to contribute to its prominent...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Ai, Gaoxiang, Huang, Ziwei, Cheng, Juanjuan, Xie, Jianhui, Zeng, Huifang, Liu, Yuhong, Li, Yucui, Huang, Xiaoqi, Chen, Jiannan, Su, Ziren
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042337/
https://ncbi.nlm.nih.gov/pubmed/33859564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.639020
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