MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway

Codeine stimulates skin mast cells and is therefore used in skin tests and as an inducer of experimental itch. MRGPRX2 responds to various drugs, including opioids, to elicit pseudoallergic reactions, but whether it represents the main opiate receptor of skin mast cells remains unknown. By combining...

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Foilsithe in:J Invest Dermatol
Main Authors: Babina, Magda, Wang, Zhao, Roy, Saptarshi, Guhl, Sven, Franke, Kristin, Artuc, Metin, Ali, Hydar, Zuberbier, Torsten
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041898/
https://ncbi.nlm.nih.gov/pubmed/33058860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.09.017
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