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MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway

Codeine stimulates skin mast cells and is therefore used in skin tests and as an inducer of experimental itch. MRGPRX2 responds to various drugs, including opioids, to elicit pseudoallergic reactions, but whether it represents the main opiate receptor of skin mast cells remains unknown. By combining...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Babina, Magda, Wang, Zhao, Roy, Saptarshi, Guhl, Sven, Franke, Kristin, Artuc, Metin, Ali, Hydar, Zuberbier, Torsten
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041898/
https://ncbi.nlm.nih.gov/pubmed/33058860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.09.017
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