Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis

Adenosine-to-inosine (A-to-I) RNA editing catalyzed by ADAR enzymes occurs in double-stranded RNAs. Despite a compelling need towards predictive understanding of natural and engineered editing events, how the RNA sequence and structure determine the editing efficiency and specificity (i.e., cis-regu...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Liu, Xin, Sun, Tao, Shcherbina, Anna, Li, Qin, Jarmoskaite, Inga, Kappel, Kalli, Ramaswami, Gokul, Das, Rhiju, Kundaje, Anshul, Li, Jin Billy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041805/
https://ncbi.nlm.nih.gov/pubmed/33846332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22489-2
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