טוען...
Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
[Image: see text] Human liver microsomes (HLM) and human hepatocytes (HH) are important in vitro systems for studies of intrinsic drug clearance (CL(int)) in the liver. However, the CL(int) values are often in disagreement for these two systems. Here, we investigated these differences in a side-by-s...
שמור ב:
| הוצא לאור ב: | Mol Pharm |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical Society
2021
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8041379/ https://ncbi.nlm.nih.gov/pubmed/33739838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.1c00053 |
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