EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1–2 signaling

BACKGROUND: Acquired chemoresistance is a major challenge in the clinical treatment of glioblastoma (GBM). Circular RNAs have been verified to play a role in tumor chemoresistance. However, the underlying mechanisms remain unclear. The aim of this study was to elucidate the potential role and molecu...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Wei, Yutian, Lu, Chenfei, Zhou, Peng, Zhao, Lin, Lyu, Xiao, Yin, Jianxing, Shi, ZhuMei, You, Yongping
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041353/
https://ncbi.nlm.nih.gov/pubmed/32926734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa214
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