Hypofractionated stereotactic re-irradiation with pembrolizumab and bevacizumab in patients with recurrent high-grade gliomas: results from a phase I study

BACKGROUND: Radiotherapy may synergize with programmed cell death 1 (PD1)/PD1 ligand (PD-L1) blockade. The purpose of this study was to determine the recommended phase II dose, safety/tolerability, and preliminary efficacy of combining pembrolizumab, an anti-PD1 monoclonal antibody, with hypofractio...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Sahebjam, Solmaz, Forsyth, Peter A, Tran, Nam D, Arrington, John A, Macaulay, Robert, Etame, Arnold B, Walko, Christine M, Boyle, Theresa, Peguero, Edwin N, Jaglal, Michael, Mokhtari, Sepideh, Enderling, Heiko, Raghunand, Natarajan, Gatewood, Tyra, Long, Wendy, Dzierzeski, Jennifer L, Evernden, Brittany, Robinson, Timothy, Wicklund, Melissa C, Kim, Sungjune, Thompson, Zachary J, Chen, Dung-Tsa, Chinnaiyan, Prakash, Yu, Hsiang-Hsuan Michael
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Clinical Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041351/
https://ncbi.nlm.nih.gov/pubmed/33173935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa260
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