ATIM-18. A PHASE I TRIAL OF HYPOFRACTIONATED STEREOTACTIC IRRADIATION (HFSRT) WITH PEMBROLIZUMAB AND BEVACIZUMAB IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMA (NCT02313272)

BACKGROUND: There is strong pre-clinical evidence for the combination of PD-1 blockade with radiotherapy and anti-VEGF therapy. Herein, we present safety and efficacy data from a phase 1 study combining pembrolizumab, an anti-PD-1 monoclonal antibody, with hypofractionated stereotactic irradiation (...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Sahebjam, Solmaz, Forsyth, Peter, Arrington, John, Jaglal, Michael, Tran, Nam D, Etame, Arnold B, Wicklund, Melissa, Drury-Sibiga, Ali, Long, Wendy, Evernden, Brittany, Gatewood, Tyra, Macaulay, Robert, Chinnaiyan, Prakash, Yu, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692068/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.113
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