ATIM-17. A PHASE I TRIAL OF HYPOFRACTIONATED STEREOTACTIC IRRADIATION (HFSRT) COMBINED WITH NIVOLUMAB (NIVO), IPILIMUMAB (IPI) AND BEVACIZUMAB (BEV) IN PATIENTS (PTS) WITH RECURRENT HIGH GRADE GLIOMAS

BACKGROUND: There is strong pre-clinical evidence that combining CTLA4 and PD-1/PDL-1 blockade with antiangiogenic agents and HFSRT independently enhance anti-tumor immune responses and tumor regression. METHODS: This phase I study includes a safety cohort of 6 pts followed by dose expansion cohort...

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Vydáno v:Neuro Oncol
Hlavní autoři: Sahebjam, Solmaz, Forsyth, Peter, Tran, Nam, Etame, Arnold, Arrington, John, Jaglal, Michael, Mokhtari, Sepideh, MacAulay, Robert, Wicklund, Melissa, Evernden, Brittany, Gatewood, Tyra, Robinson, Timothy, Raval, Raju, Yu, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Adult Clinical Trials–Immunologic
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847102/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.017
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