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Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif

Stabilization of Torpedo californica acetylcholinesterase by the divalent cations Ca(+2), Mg(+2), and Mn(+2) was investigated. All three substantially protect the enzyme from thermal inactivation. Electron paramagnetic resonance revealed one high‐affinity binding site for Mn(+2) and several much wea...

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Dettagli Bibliografici
Pubblicato in:Protein Sci
Autori principali: Silman, Israel, Shnyrov, Valery L., Ashani, Yacov, Roth, Esther, Nicolas, Anne, Sussman, Joel L., Weiner, Lev
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040873/
https://ncbi.nlm.nih.gov/pubmed/33686648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4061
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