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Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase

The photosensitizer, methylene blue (MB), generates singlet oxygen that irreversibly inhibits Torpedo californica acetylcholinesterase (TcAChE). In the dark, it inhibits reversibly. Binding is accompanied by a bathochromic absorption shift, used to demonstrate displacement by other acetylcholinester...

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Detaylı Bibliyografya
Asıl Yazarlar: Paz, Aviv, Roth, Esther, Ashani, Yacov, Xu, Yechun, Shnyrov, Valery L, Sussman, Joel L, Silman, Israel, Weiner, Lev
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley Subscription Services, Inc., A Wiley Company 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537235/
https://ncbi.nlm.nih.gov/pubmed/22674800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2101
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