Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase

The photosensitizer, methylene blue (MB), generates singlet oxygen that irreversibly inhibits Torpedo californica acetylcholinesterase (TcAChE). In the dark, it inhibits reversibly. Binding is accompanied by a bathochromic absorption shift, used to demonstrate displacement by other acetylcholinester...

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Библиографические подробности
Главные авторы: Paz, Aviv, Roth, Esther, Ashani, Yacov, Xu, Yechun, Shnyrov, Valery L, Sussman, Joel L, Silman, Israel, Weiner, Lev
Формат: Artigo
Язык:Inglês
Опубликовано: Wiley Subscription Services, Inc., A Wiley Company 2012
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537235/
https://ncbi.nlm.nih.gov/pubmed/22674800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2101
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