Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses

Although Powassan virus (POWV) is an emerging tick-transmitted flavivirus that causes severe or fatal neuroinvasive disease in humans, medical countermeasures have not yet been developed. Here, we developed a panel of neutralizing anti-POWV mAbs recognizing six distinct antigenic sites. The most pot...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: VanBlargan, Laura A., Errico, John M., Kafai, Natasha M., Burgomaster, Katherine E., Jethva, Prashant N., Broeckel, Rebecca M., Meade-White, Kimberly, Nelson, Christopher A., Himansu, Sunny, Wang, David, Handley, Scott A., Gross, Michael L., Best, Sonja M., Pierson, Theodore C., Fremont, Daved H., Diamond, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040518/
https://ncbi.nlm.nih.gov/pubmed/33831142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20210174
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