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Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

PURPOSE: The risk for age-related macular degeneration has been tied to an overactive complement system. Despite combined attempts by academia and industry to develop therapeutics that modulate the complement response, particularly in the late geographic atrophy form of advanced AMD, to date, there...

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Bibliografski detalji
Izdano u:Invest Ophthalmol Vis Sci
Glavni autori: Annamalai, Balasubramaniam, Parsons, Nathaniel, Nicholson, Crystal, Obert, Elisabeth, Jones, Bryan, Rohrer, Bärbel
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039473/
https://ncbi.nlm.nih.gov/pubmed/33830174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.4.11
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