Magnitude of Off-Target Allo-HLA Reactivity by Third-Party Donor-Derived Virus-Specific T Cells Is Dictated by HLA-Restriction

T-cell products derived from third-party donors are clinically applied, but harbor the risk of off-target toxicity via induction of allo-HLA cross-reactivity directed against mismatched alleles. We used third-party donor-derived virus-specific T cells as model to investigate whether virus-specificit...

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Publicado en:Front Immunol
Autores principales: Huisman, Wesley, Leboux, Didier A. T., van der Maarel, Lieve E., Hageman, Lois, Amsen, Derk, Falkenburg, J. H. Frederik, Jedema, Inge
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039299/
https://ncbi.nlm.nih.gov/pubmed/33854504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.630440
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