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Transcription factor competition at the γ-globin promoters controls hemoglobin switching
BCL11A, the major regulator of HbF(α(2)γ(2)) level, represses γ-globin expression through direct promoter binding in adult erythroid cells in a switch to adult-type HbA (α(2)β(2)). To uncover how BCL11A initiates repression, we used CRISPR/Cas9, dCas9, dCas9-KRAB, and dCas9-VP64 screens to dissect t...
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| Publicado no: | Nat Genet |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8038971/ https://ncbi.nlm.nih.gov/pubmed/33649594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00798-y |
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