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Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis

Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To determine how co-transcriptional splicing is integrated with transcription elongation and 3′ end formation in mammalian cells, we performed long-read sequencing of individual nascent RNAs and PRO-seq during mo...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Reimer, Kirsten A., Mimoso, Claudia, Adelman, Karen, Neugebauer, Karla M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038867/
https://ncbi.nlm.nih.gov/pubmed/33440169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.018
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