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The Effect of Oxidized Dopamine on the Structure and Molecular Chaperone Function of the Small Heat-Shock Proteins, αB-Crystallin and Hsp27

Oxidation of the neurotransmitter, dopamine (DA), is a pathological hallmark of Parkinson’s disease (PD). Oxidized DA forms adducts with proteins which can alter their functionality. αB-crystallin and Hsp27 are intracellular, small heat-shock molecular chaperone proteins (sHsps) which form the first...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Hayashi, Junna, Ton, Jennifer, Negi, Sparsh, Stephens, Daniel E. K. M., Pountney, Dean L., Preiss, Thomas, Carver, John A.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037807/
https://ncbi.nlm.nih.gov/pubmed/33918165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073700
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