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In Silico Design and Selection of New Tetrahydroisoquinoline-Based CD44 Antagonist Candidates
CD44 promotes metastasis, chemoresistance, and stemness in different types of cancer and is a target for the development of new anti-cancer therapies. All CD44 isoforms share a common N-terminal domain that binds to hyaluronic acid (HA). Herein, we used a computational approach to design new potenti...
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| Опубликовано в: : | Molecules |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
MDPI
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8037692/ https://ncbi.nlm.nih.gov/pubmed/33810348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26071877 |
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