Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease

Niemann–Pick type C (NPC) disease is a rare autosomal recessive inherited childhood neurodegenerative disease characterized by the accumulation of cholesterol and glycosphingolipids, involving the autophagy-lysosome system. Inhibition of soluble epoxide hydrolase (sEH), an enzyme that metabolizes ep...

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Foilsithe in:Int J Mol Sci
Main Authors: Griñán-Ferré, Christian, Companys-Alemany, Júlia, Jarné-Ferrer, Júlia, Codony, Sandra, González-Castillo, Celia, Ortuño-Sahagún, Daniel, Vilageliu, Lluïsa, Grinberg, Daniel, Vázquez, Santiago, Pallàs, Mercè
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2021
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036710/
https://ncbi.nlm.nih.gov/pubmed/33810307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073409
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