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Generation of a Human Neuronal Stable Cell Model for Niemann-Pick C Disease by RNA Interference
Niemann–Pick type C (NPC) disease is a fatal autosomal recessive neurodegenerative disorder caused, most commonly, by mutations in the NPC1 gene. At the cellular level, the disease is characterized by the storage of multiple lipids in the endosomal–lysosomal system, including free cholesterol, glyco...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3509875/ https://ncbi.nlm.nih.gov/pubmed/23430894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/8904_2011_64 |
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