5-Aza-2′-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells

A generation of induced pluripotent stem cells (iPSC) by ectopic expression of OCT4, SOX2, KLF4, and c-MYC has established promising opportunities for stem cell research, drug discovery, and disease modeling. While this forced genetic expression represents an advantage, there will always be an issue...

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Udgivet i:Molecules
Main Authors: Aguirre-Vázquez, Alain, Salazar-Olivo, Luis A., Flores-Ponce, Xóchitl, Arriaga-Guerrero, Ana L., Garza-Rodríguez, Dariela, Camacho-Moll, María E., Velasco, Iván, Castorena-Torres, Fabiola, Dadheech, Nidheesh, Bermúdez de León, Mario
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036574/
https://ncbi.nlm.nih.gov/pubmed/33805347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26071909
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