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Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells
More than 90% of colorectal cancers carry mutations in Apc that drive tumourigenesis. A 'just-right' signalling model proposes that Apc mutations stimulate optimal, but not excessive Wnt signalling, resulting in a growth advantage of Apc mutant over wild-type cells. Reversal of this growth...
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| 出版年: | Cell Death Dis |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5833359/ https://ncbi.nlm.nih.gov/pubmed/29449562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0199-9 |
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