Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease

Chagas disease, caused by the parasite Trypanosoma cruzi (T. cruzi), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense cardiac fibrosis and inflammation are hallmarks of chronic Chagas disease cardiomyopathy (CCC). Previously, we identifi...

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Pubblicato in:Int J Mol Sci
Autori principali: Nonaka, Carolina Kymie Vasques, Sampaio, Gabriela Louise, de Aragão França, Luciana, Cavalcante, Bruno Raphael, Silva, Katia Nunes, Khouri, Ricardo, Torres, Felipe Guimarães, Meira, Cassio Santana, de Souza Santos, Emanuelle, Macedo, Carolina Thé, Paredes, Bruno Diaz, Rocha, Vinicius Pinto Costa, Rogatto, Silvia Regina, Ribeiro dos Santos, Ricardo, Souza, Bruno Solano de Freitas, Soares, Milena Botelho Pereira
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036348/
https://ncbi.nlm.nih.gov/pubmed/33804922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073307
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