Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease

Chagas disease, caused by the parasite Trypanosoma cruzi (T. cruzi), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense cardiac fibrosis and inflammation are hallmarks of chronic Chagas disease cardiomyopathy (CCC). Previously, we identifi...

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Publicado en:Int J Mol Sci
Autores principales: Nonaka, Carolina Kymie Vasques, Sampaio, Gabriela Louise, de Aragão França, Luciana, Cavalcante, Bruno Raphael, Silva, Katia Nunes, Khouri, Ricardo, Torres, Felipe Guimarães, Meira, Cassio Santana, de Souza Santos, Emanuelle, Macedo, Carolina Thé, Paredes, Bruno Diaz, Rocha, Vinicius Pinto Costa, Rogatto, Silvia Regina, Ribeiro dos Santos, Ricardo, Souza, Bruno Solano de Freitas, Soares, Milena Botelho Pereira
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036348/
https://ncbi.nlm.nih.gov/pubmed/33804922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073307
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