Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy

Chagas disease cardiomyopathy is a parasite-driven inflammatory disease to which there are no effective treatments. Here we evaluated the therapeutic potential of N,N-dimethylsphingosine(DMS), which blocks the production of sphingosine-1-phosphate(S1P), a mediator of cellular events during inflammat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vasconcelos, Juliana Fraga, Meira, Cássio Santana, Silva, Daniela Nascimento, Nonaka, Carolina Kymie Vasques, Daltro, Pâmela Santana, Macambira, Simone Garcia, Domizi, Pablo Daniel, Borges, Valéria Matos, Ribeiro-dos-Santos, Ricardo, de Freitas Souza, Bruno Solano, Soares, Milena Botelho Pereira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522404/
https://ncbi.nlm.nih.gov/pubmed/28733584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06275-z
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