(+)-[(18)F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls

PURPOSES: We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)–targeting radioligand (+)-[(18)F]Flubatine. Aims were to develop a kinetic modeling-based approach to quantify (+)-[(18)F]Flubatine and compare the data of healthy controls (HCs) a...

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Bibliografiske detaljer
Udgivet i:Eur J Nucl Med Mol Imaging
Main Authors: Tiepolt, Solveig, Becker, Georg-Alexander, Wilke, Stephan, Cecchin, Diego, Rullmann, Michael, Meyer, Philipp M., Barthel, Henryk, Hesse, Swen, Patt, Marianne, Luthardt, Julia, Wagenknecht, Gudrun, Sattler, Bernhard, Deuther-Conrad, Winnie, Ludwig, Friedrich-Alexander, Fischer, Steffen, Gertz, Hermann-Josef, Smits, René, Hoepping, Alexander, Steinbach, Jörg, Brust, Peter, Sabri, Osama
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036219/
https://ncbi.nlm.nih.gov/pubmed/32935187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-020-05029-w
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