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Exploring the Metabolism of (+)-[(18)F]Flubatine In Vitro and In Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study †
Both (+)-[(18)F]flubatine and its enantiomer (−)-[(18)F]flubatine are radioligands for the neuroimaging of α4β2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). In a clinical study in patients with early Alzheimer’s disease, (+)-[(18)F]flubatine ((+)-[(18)F]1) was ex...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6017759/ https://ncbi.nlm.nih.gov/pubmed/29461507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23020464 |
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