Exploring the Metabolism of (+)-[(18)F]Flubatine In Vitro and In Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study †

Both (+)-[(18)F]flubatine and its enantiomer (−)-[(18)F]flubatine are radioligands for the neuroimaging of α4β2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). In a clinical study in patients with early Alzheimer’s disease, (+)-[(18)F]flubatine ((+)-[(18)F]1) was ex...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Ludwig, Friedrich-Alexander, Fischer, Steffen, Smits, René, Deuther-Conrad, Winnie, Hoepping, Alexander, Tiepolt, Solveig, Patt, Marianne, Sabri, Osama, Brust, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017759/
https://ncbi.nlm.nih.gov/pubmed/29461507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23020464
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